Central giant cell granuloma of the mandible american. This group of lesions includes central giant cell granuloma cgcg, giant cell tumor of long bones, aneurysmatic bone cyst, brown tumor of hyperparathyroidism. The diagnosis and management of giant cell lesions of the jaws. Because of its overwhelming incidence on the gingiva, the condition is associated with two other diseases, pyogenic granuloma. Conventional management is surgical and consists of enucleation and curettage. Resume le cherubisme est une affection tumorale rare.
Peripheral giantcell granuloma pgcg is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. This case report describes a 19yearold female patient with a central giant cell granuloma in the left mandibular condyle, treated with en bloc resection. Clinical and radiographic features of chronic monostotic. This peripheral giant cell granuloma involved the maxillary gingiva associated with an erupting central incisor of a 6yearold girl. Aggressive and nonaggressive form, central giant cell granuloma. Central giant cell lesion cgcl is a benign lesion which has unpredictable biologic behaviour and is amenable to a plethora of treatment alternatives. It occurs most commonly on the mandible than in maxilla.
Central giant cell granuloma cgcg of the jaw is a benign osteolytic lesion. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Here we present a case report of a 45yearold woman. Read maxillary central giant cell granuloma in a dog, journal of small animal practice on deepdyve, the largest online rental service for scholarly research with thousands of academic. Fibrome cementoossifiant peripherique maxillaire posterieur fibrome cementoossifiant peripherique maxillaire posterieur fibrome ossifiant mandibulaire associe a une canine incluse journal of oral medicine and oral surgery, apr 20. Central giant cell granuloma cgcg is an uncommon, benign, and proliferative lesion of the jaw with an unknown etiology. The central giant cell granuloma is an uncommon, benign and proliferative pathological condition accounting for less than 7% of all benign lesions of the jaws whose etiology is not clearly. Cgcg accounts for less than 7 % of all benign lesions of mandible and maxilla. Invasive fungal infections may pre this is evident on ct. The patient was unaware of the lesion and did not know for how long it had been present.
Historically, the lesion has been referred to by numerous terms, including myeloid sarcoma, tumor of myeloplaxus, osteoblastoclastoma, and osteoclastoma, 2, 5. Case report giant cell granuloma of the maxilla usman haider uzbek, iram mushtaq oral and maxillofacial unit, department of dentistry, ayub medical college, abbottabad. Simultaneous maxillary and mandibular brown tumors as the first presentation of secondary hyperparathyroidism. Giant cell reparative granuloma or central giant cell granuloma is a benign tumor of the jaws, of unknown etiology. While references to thelesions in lung are numerous and the changes caused by silicates in the muscle, peritoneum and serosa.
We present two cases of central giant cell granuloma in the temporal bone. Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. Tumeurs et pseudotumeurs des maxillaires riches en cellules geantes. Traditional treatment has been local curettage, although aggressive subtypes. Giant cell central granuloma gccg is an uncommon pseudotumor. A clinical report, the journal of prosthetic dentistry, 99, 4, 257, 2008. The central giant cell granuloma is an uncommon, benign and proliferative lesion whose etilogy is not well defined. Occasionally this type of lesion may recur, and periodic observation is strongly advised. An aggressive central giant cell granuloma treated successfully by. It is twice as common in females and is more likely to occur before age 30. Brown tumor of hyperparathyroidism masquerading as central giant cell granuloma in a renal transplant recipient. Central giant cell granuloma cgcg is an uncommon benign bony. Central giant cell granuloma is a benign intraosseous lesion.
The central giant cell granuloma cgcg is an uncommon benign bony lesion that accounts for less than 7% of all benign lesions of the jaws in toothbearing areas. Central giant cell granuloma of the posterior maxilla. Central giant cell granuloma cgcg is a rare and benign intraosseous lesion that usually occurs in the mandible and the maxilla. Please check back soon, as we will revert to usual policy as soon as possible. It is microscopically similar to the central giant cell granuloma of. Pdf fibrome ossifiant mandibulaire associe a une canine incluse. Despite this, a recurrence rate of 1520% is often quoted, and in these cases treatment may need to be more aggressive and may need to consist of an en bloc resection. Giantcell tumors of the sphenoid bone in four children. Peripheral giant cell granuloma or the socalled giant cell epulis is the most common oral giant cell lesion.
Central giant cell granuloma formerly called as giant cell reparative granuloma is a non neoplastic proliferative lesion of unknown etiology. Clinically and radiologically, a differentiation between aggressive and nonaggressive lesions can be made. Granulome reparateur central a cellules geantes grccg em. Clinically and radiologically, a differentiation between aggressive and nonaggressive lesions. The most common clinical finding was headache, followed by cranial nerve abnormalities. The most common treatment is curettage,which has a high recurrence rate, particularly in more. Both acute and chronic forms usually extensively bony rim with a heterogeneous central cavity. The interprofessional treatment team included an oral and maxillofacial surgeon, maxillofacial prosthodontist, dentist, orthodontist, and speechlanguage pathologist, and treatment spanned 9 years. Most cgcgs are asymptomatic with gradual painless bony enlargement. Case report giant cell tumor of the maxilla in an 8 year old boy sabhlok s1, shaikh mi2, tripathy r3, mishra s4. It is therefore essential to eliminate an associated calcium phosphate disorder, as the treatment of.
A 57yearold caucasian woman who had suffered a traumatic injury 39 years previously developed a central giant cell reparative granuloma which was treated successfully by concomitant endodontic therapy and surgical enucleation. Full text pdf downloads of subscription based journal articles will not be available we apologise for any inconvenience caused. Unlike brown tumours, central giant cell granuloma is always an isolated lesion, exclusively involving the maxillofacial region, usually the mandible. A longterm followup drake mcarthur1, enrique palacios, md, facr, dabr2, and jeremy nguyen, md1 abstract this is a case of a 32yearold. Central giant cell granuloma is a benign lesion of the jaws which is sometimes aggressive locally. Sep 23, 2004 the earliest known case dates to about 2,000 years ago and is from poland. One such reactive lesion is the peripheral ossifying fibroma pof, a gingival nodule composed of a cellular fibroblastic connective tissue stroma associated with the formation of randomly dispersed foci of mineralized product consisting of bone. Giant cell tumor gct of bone was first described by sir astley cooper in 1818, 1. Central giantcell is a benign lesion that predominantly involves the bone of the mandible and maxilla with a wide varia. It was jaffe who first introduced the term central giant cell reparative granuloma. Who categorize it as a bonerelated lesion, not a tumor, although its clinical behavior and radiographic features often are those. Peripheral giant cell granuloma pubmed central pmc. The differential diagnosis was some type of odontogenic lesion such as a keratocyst or ameloblastoma, a central giant cell granuloma or idiopathic bone cavity.
Ct showed an enhancing tumor causing a smoothly margined temporal squamosa and floor of the middle. Treatment included surgical resection of a central giant cell granuloma. Pdf central giant cell granuloma of mandible mohit. Incidence and diseasefree survival after surgical therapy of central giant cell granulomas of the jaw in the netherlands. Central giant cell granuloma is an uncommon benign proliferative. These lesions occur 23 times more frequently in mandible than in maxilla. It occurs most commonly in the mandible than in the maxilla. Pathology of the head and neck antonio cardesa pieter j. Maxillary central giant cell granuloma in a dog, journal. An aggressive central giant cell granuloma in a pediatric patient.
Radiotherapy for recurrent central giant cell granuloma. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of unknown. Pdf central giant cell granuloma of the anterior maxilla. Central giant cell granuloma condyle mandible intraosseous abstract introduction. The maxillary sinus human anatomy human head and neck. Pathology of the head and neck with 249 figures in 308 separate illustrations and 17 tables. Divided into non and aggressive subtypes, the aggressive subtype is relatively rare and can occasionally progress rapidly, resulting in significant morbidity.
We present a case of an aggressive central giant cell granuloma. Current therapy in oral and maxillofacial surgery ebook. Central giant cell granuloma is an uncommon benign intraosseus lesion of jaws. On biopsy, the mass in our case turned out to be a giant cell granuloma, formally called giant cell reparative granuloma, which is a distinct entity from a giant cell tumor and in. Central giant cell granulomas cgcg of the jaw are uncommon benign lesions which usually occur in the mandible in young adults. Central giant cell lesions granulomas, also known as giant cell reparative. Central giant cell granulomas of the condyle are rare.
Case report giant cell tumor of the maxilla in an 8 year. Recurrent central giant cell granuloma in the mandible. Central giant cell granuloma of the anterior maxilla. Simultaneous maxillary and mandibular brown tumors as the. It may exhibit aggressive biologic behavior, characterized by localized swelling, pain, rapid growth, bony. The importance of biopsy in making the diagnosis is emphasised because surgical treatment of central giant cell granuloma. In 1953, jaffe described it as reparative granuloma of jaw. Maxillary central giant cell granuloma in a dog johnson. Central giant cell granuloma cgcg is a non neoplastic benign process. Coniglio and matthew palermo, oral rehabilitation of a 12yearold patient diagnosed with a central giant cell granuloma using a fibula graft and an implantsupported prosthesis. The mission of the pamj is to create, stimulate and perpetuate a culture of information sharing and publishing amongst researchers and other health actors of the african health scene in ways that will contribute to improve availability of health information, a better understanding of africa specificities,and overall, to improve health outcomes in the continent.
The treatment of hyperparathyroidism is the first step in the management of the brown tumor 14. Central giant cell granuloma cgcg is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells and. Peripheral giant cell granuloma associated with the eruption of a maxillary central incisor. Central giant cell granuloma cgcg is a benign bone lesion which can be locally aggressive or may be asymptomatic in nature. A certain diagnosis was confirmed by the endocrinologic status of the patient. Central giant cell granuloma is a rather rare lesion of the jaws aetiology of. Treatment of severe atrophy of the maxilla with the. Imaging of giant cell tumor and giant cell reparative. An aggressive central giant cell granuloma in a pediatric. It normally presents as a soft tissue purplishred nodule consisting of. The bony rim involve nasal mucosa as well as the sinuses and can be clas is distinct from the surrounding bone, and in most cases sified as rhinosinusitis. Central giant cell granulomas cgcg of the jaw are uncommon benign lesions which usually occur in the. Case report resection laparoscopique dune duplication gastrique chez ladulte. Read current cancer literature, cancer on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Central giant cell lesions granuloma dr yuranga weerakkody and assoc prof frank gaillard et al. We report the clinical pathological and radiological findings of giant cell tumor of the sphenoid bone in four children aged 10 to 16 years. For the previously reported cases in one female and three males, the mean age at presentation was 30 years. Central giant cell granuloma cgcg is a benign lesion of the jaws with an unknown etiology. Written by expert surgeons and educators, current therapy in oral and maxillofacial surgery covers the latest treatment strategies, surgical techniques, and potential complications in oms. San francisco the harmful effects on the human body of silica and certain silicates have been known for many years. Fibrome ossifiant mandibulaire associe a une canine incluse. Cgcg was formerly regarded as a reparative process and was, accordingly, called central giant cell reparative granuloma.
Who categorize it as a bonerelated lesion, not a tumor, although its clinical. Full text pdf downloads of open access journal articles will be available as always. Peripheral giant cell granuloma central giant cell granuloma. A central giant cell granuloma in posterior part of. Giant cell central granuloma gccg is an uncommon pseudotumor of the maxilla. Also called giant cell reparative granuloma central if intraosseous. The central giant cell granuloma is an uncommon, benign and proliferative pathological condition accounting for less than 7% of all benign lesions of the jaws whose etiology is not clearly explained. Radiological and epidemiological aspects of central giant cell. Sep 01, 2001 the radiologic features of giant cell tumor gct and giant cell reparative granuloma gcrg of bone often strongly suggest the diagnosis and reflect their pathologic appearance. Central giant cell granuloma of the maxilla bmj case reports. Antiquity of cancer capasso 2005 international journal. Central giantcell granuloma cgcg is a localised benign condition of the jaws. Most mandibular lesions occur anterior to first molars.
Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of an unknown aetiology. Pdf peripheral giant cell granuloma associated with the. Pdf central giant cell granuloma of the temporal bone. Case report open access radiotherapy for recurrent central giant cell granuloma. It has similar clinical, radiological and histological features to those of brown tumour. Solitary gingival enlargements in children are relatively common finding and are usually the result of a reactive response to local irritation.
Brown tumor of the palate as first manifestation of primary. The central giant cell granuloma is an uncommon, benign and proliferative lesion whose eti categorize it as a bonerelated lesion, not a tumor, although its clinical behavior and. All of these lesions have almost similar age distribution, clinical features and radiographic manifestation. Cgcg accounts for less than 7% of all benign lesions of mandible and maxilla. Considering its location and clinical presentation, this painless tumor can resemble an odontogenic cellulitis. Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing central giant cell granuloma cgcg is a lesion that appears to be unique to the jaws, 1115 although the socalled giant cell reaction of the hands and feet shares many features. The central giant cell granulomacgcg of bone constitutes about 10% of benign jawbone lesions. The first type is nonaggressive, slow growing, does not show root resorption or cortical perforation, and often shows new bone. Clinicopathological profile of central giant cell granulomas. Intraosseous schwannoma mimicking a neoplasms benign tumor. These lesions occur 23 times more frequently in mandible than in maxilla 1. It affects females more often than males, mandible than.
1312 873 1509 1221 755 386 1304 975 56 807 833 898 1573 1198 745 1202 1247 1292 768 1043 766 282 955 942 773 1571 560 1292 78 670 1052 998 1192 1350 918 442 327 177 293 254 284